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« Motivation | Main | The Passing of the Crazy Diamond »

July 10, 2006


Daniel Haszard

My issue is Zyprexa which is only FDA approved for schizophrenia (.5-1% of pop) and some bipolar (2% pop) and then an even smaller percentage of theses two groups.
So how does Zyprexa get to be the 7th largest drug sale in the world?

Eli Lilly is in deep trouble for using their drug reps to 'encourage' doctors to write zyprexa for non-FDA approved 'off label' uses.

The drug causes increased diabetes risk,and medicare picks up all the expensive fallout.There are now 7 states (and counting) going after Lilly for fraud and restitution.

Daniel Haszard

Richard Petty

IF pharmaceutical representatives were promoting "off label" that would obviously be wrong. I don't know of any examples where the company - as opposed to over zealous individuals - were doing so. I think that is what all the investigations are about.

Doctors constantly have to use medicines "off label." They cannot say that, "There is published data that drug X will help, but since it isn't apporved for that indication I am going to withhold tretament." Every single treatment decision should involve a careful risk/benefit evaluation.

The balance of evidence does now seem to indicate a slight increase in diabetes risk with several psychotropic medicines, though there is more research on the topic coming. And secondly, it is essential to confirm whether some of these psychotropics are diseases modifying agents. If indeed they are, as some evidence suggests, then that would probably out-weigh a presumptive metabolic effect.

Kind regards,


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