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February 19, 2007


Reg Adkins

Dr. Petty,
Would you be willing to hazard an estimation as to whether Zoloft (the Pfiser brand of setraline) has the same tendancy of inducing weight gain?

Richard Petty

Dear Reg,

There's a very large amount of published data on the propensity of different antidepressants and mood stabilizers to cause weight gain. Some do it more than others, and it is usually idiosyncratic: some people gain a lot and some none at all.

Sertraline is well known to cause weight gain in some people. It usually starts after a few months and then usually stops again.

The mechanism is probably not the same as it is with antipsychotics. I say that based on pharmacology and also on the different patterns of weight gain seen with medicines like clozapine and olanzapine and antidepressants such as sertraline and mirtazapine.

Kind regards,


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